Living Medical Textbook - Hematology - Projects In Knowledge - Insights into Managing Leukemia Table of Contents

Very Often

Not Very Often

Order flow cytometry testing to diagnose what type of leukemia a patient has

Discuss prognosis with patients based on results of genetic testing of the leukemia

Utilize a formal classification system (FAB or WHO) to evaluate the prognosis for an AML patient

Consider the karyotype of a leukemia in selecting a therapy

Living Medical
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From Projects In Knowledge

Hematology

Insights into Managing Leukemia

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Chapter 1
Overview of Leukemia
Last Reviewed: May 14, 2010

–	Overview of Leukemogenesis
–	Clinical Characteristics
–	Genetics of Leukemia
–	Diagnostic Methods
–	References

Chapter 2
Release date: May 14, 2010

Chapter 3
Release date: May 14, 2010

This independent CME/CE activity is supported by an educational grant from Bristol-Myers Squibb and Novartis Pharmaceuticals Corporation..

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This CME program will include a brief pretest. Please start now by answering these 4 questions:

Using flow cytometry, a diagnosis of leukemia is made if the following are found in peripheral blood: *

	Elevated numbers of cells positive for both CD20 and CD34
	Elevated numbers of CD3 positive T-cells
	Monoclonal cell surface immunoglobulin
	Aberrant patterns of antigens (LAP)

The following presenting symptoms would lead a clinician to suspect acute myeloid leukemia (AML): *

	Infections of the chest, bladder, skin, and sinuses, accompanied by high fever and leukemia cutis
	Lymphadenopathy, leukocytosis, drenching night sweats, and rapid unintentional weight loss
	Pallor, cardiac flow murmur, and hepatomegaly
	Fatigue, malaise, weakness, low fever/chills, and pallor

A 3-year-old presents with lymphadenopathy, signs of anemia, oral ulcers, and petechiae. The referring physician reports that she has a low red cell count. You might request the following tests as a first step: *

	Peripheral blood cytochemistry and karyotyping and a CBC to check for neutropenia, anemia, and thrombocytopenia
	Flow cytometry of peripheral blood leukocytes to check for surface antigens
	Karyotyping of peripheral blood lymphocytes to check for translocation t(12:21)
	FISH of peripheral blood lymphocytes to check for nucleoli

How often do you currently use each of the following clinical practice strategies?